ABSTRACT
This research was aimed to develop the technique and formula for the preparation of stable and effective microbubbles containing hydrophilic drugs. We prepared EB-PLGA microbubbles and evaluated its drug loading and burst release to choose the best technique and formula. The result of optimizing formula was W1/O (1:15), EB-PLGA (0.04), PVA (5%). The burst release decreased after the addition of supplemental agent and the change of method for preparation. We concluded that the optimizing formula could elevate drug loading and decrease burst release obviously.
Subject(s)
Drug Carriers , Chemistry , Lactic Acid , Chemistry , Microbubbles , Polyglycolic Acid , Chemistry , Quality ControlABSTRACT
Objective To investigate the value of color Doppler ultrasonography in early diagnosis and subsequent follow-up of the transient synovitis of the hip in children. Methods Color Doppler ultrasonography was performed on 80 children with transient synovitis of the single hip, and the characteristics of the blood signal changes in the synovial membrane of the hip joint were observed before treatment, 4 days and 8 days after treatment, while the normal hip joints were examined as the controls. Results Abnormalities in the injured side of the hip joints were displayed in all 80 children. Obviously increased blood signal of the injured side was detected with injured before treatment, but gradually decreased 4 days after treatment, and became similar to the healthy side after 8 days. Conclusion CDFI has an important role in monitoring changes of blood supply, and affords clinical application value in the therapeutic effect observation in transient synovitis of the hip in children.
ABSTRACT
0.05) before and after the contrast.However,for the renal parenchyma,it increased significantly after the contrast(P